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      當前位置:首頁 > 資訊信息 > 新聞動態 > 詳細信息
      研究發現用小分子RNA抑制乳腺癌的方法
      來源:研究發現用小分子RNA抑制乳腺癌的方法 | 作者: | 發布時間:2014-10-30 8:37:04



      從中國科學技術大學獲悉,該校生命學院柳素玲教授在腫瘤干細胞領域研究中取得新突破,發現一種叫做 microRNA100(miR-100)的核糖核酸小分子可以抑制乳腺腫瘤干細胞的更新和增殖,從而扼制乳腺癌的生長和遷移。

      在此項研究中,中國科大科研人員發現,miR-100的表達水平與細胞的分化狀態相關,在乳腺腫瘤干細胞中,miR-100表達水平很低,從而促進了乳腺腫瘤干細胞的分化。而利用四環素誘導型慢病毒在乳腺腫瘤細胞中提高miR-100表達,就能減少乳腺腫瘤干細胞的生成。

      進一步的機制研究表明,miR-100是通過下調乳腺腫瘤干細胞的一些調控基因包括SMARCA5、SMARCD1和BMPR2等的表達,在腫瘤細胞實驗及小鼠實驗中都抑制了癌細胞增殖。他們還將腫瘤細胞植入到小鼠乳腺脂肪墊和注射到小鼠心臟,并在小鼠體內立刻誘導miR-100的高表達,發現可以阻止腫瘤生長和轉移。此外,他們通過納米載體將miR-100輸送到腫瘤干細胞里,從而抑制了腫瘤的生長。在臨床上,他們觀察到乳腺癌樣本中miR-100含量與患者存活率顯著的正相關。

      《癌癥研究》雜志審稿人評論說,此研究第一次深刻闡述了miR-100對乳腺腫瘤的影響,并且為microRNA與腫瘤干細胞的密切相關性以及乳腺癌研究和治療提供了新的理念和方向。

      柳素玲表示,該研究證明了miR-100在調控乳腺腫瘤干細胞的自我更新和分化中起著至關重要的作用,這為針對乳腺腫瘤干細胞的治療提供了新的靶點。


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