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      我科學家發現細胞“返老還童”機制
      來源:我科學家發現細胞“返老還童”機制 | 作者: | 發布時間:2014-10-30 8:41:56

      我國科學家發現了一種新細胞生物學機制,有望推動誘導多能干細胞技術更快地應用到疾病治療中。中科院廣州生物醫藥與健康研究院研究員裴端卿、鄭輝的團隊完成的這一研究成果26日在線發表于國際學術期刊《自然·細胞生物學》。

      據介紹,誘導多能干細胞過程可以將人體內的普通細胞“逆轉”回到早期胚胎發育狀態,從而重新獲得分化成為體內絕大多數種類細胞的能力,建立該技術的科學家憑此獲得了2012年度諾貝爾生理或醫學獎。這一細胞水平的“返老還童”過程蘊藏著眾多生命奧秘,但目前人們對其知之甚少。

      早在2010年,裴端卿團隊就發現,細胞“逆轉”過程是由間充質細胞狀態轉變到上皮細胞狀態來驅動的。在進一步的研究中,裴端卿、鄭輝團隊通過優化轉化因子導入的順序,發現在間充質轉變到上皮細胞狀態前還存在一個上皮向間充質細胞狀態轉換過程,并證明這樣的多次轉換有利于提高重編程效率。這一新細胞生物學機制有望推動誘導多能干細胞研究的理論和實踐突破,為干細胞治療帕金森等退行性疾病開辟新途徑。

      《世界復合醫學》

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