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      尿素通道蛋白B的轉運特性
      來源: | 作者: | 發布時間:2014-4-15 16:05:53

      尿素通道蛋白B的轉運特性
      鐘丹丹,楊寶學
      基金項目:國家自然科學基金(No.30870921,81170632,81261160507)、科技部國際科技合作與交流專項(No.2012DFA11070)、教育部高等學校博士學科點專項科研基金(No.20100001110047) 作者簡介:鐘丹丹(1990),女,碩士研究生,藥理學 通信聯系人:楊寶學,男,教授,藥理學.

      (天然藥物及仿生藥物國家重點實驗室,北京大學基礎醫學院藥理學系,北京,100191)

      摘要:尿素通道蛋白B(urea transporters B, UT-B)主要表達在紅細胞和一些上皮及內皮細胞膜,介導尿素的跨膜轉運。近年來研究發現UT-B亦參與其他物質的轉運,如水、NH3和尿素類似物等,提示UT-B還可以作為水和氣體通道。本文主要闡述UT-B對這些物質的轉運特性,并探究其可能的生理學意義。
      關鍵詞:尿素通道蛋白B;尿素;尿素類似物;NH3;水
      中圖分類號:R96
      Transport characteristics of urea transporter-B
      Zhong Dandan1,2, Yang Baoxue1,2
      (1. State Key Laboratory of Natural and Biomimetic Drugs; 15 2.
      Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, 100191)
      Abstract: Urea transporter UT-B is highly expressed in the membrane of erythrocytes and some epithelial and endothelial cells, in which UT-B facilitates urea transport. Recently, studies found that 20 water, ammonia and urea analogues can also be transported by UT-B. This review mainly focus on the transport characteristics of UT-B, and the possible physiological significance will be discussed as well.
      Key words: UT-B; urea; urea analogues; ammonia; water

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